The Phytophthora RXLR Effector Avrblb2 Modulates Plant Immunity by Interfering With Ca2+ Signaling Pathway.
Identifieur interne : 000372 ( Main/Exploration ); précédent : 000371; suivant : 000373The Phytophthora RXLR Effector Avrblb2 Modulates Plant Immunity by Interfering With Ca2+ Signaling Pathway.
Auteurs : Zunaira Afzal Naveed [États-Unis] ; Shaheen Bibi [États-Unis] ; Gul Shad Ali [États-Unis]Source :
- Frontiers in plant science [ 1664-462X ] ; 2019.
Abstract
In plants, subcellular fluctuations in Ca2+ ion concentration are among the earliest responses to biotic and abiotic stresses. Calmodulin, which is a ubiquitous Ca2+ ion sensor in eukaryotes, plays a major role in translating these Ca2+ signatures to cellular responses by interacting with numerous proteins located in plasma membranes, cytoplasm, organelles and nuclei. In this report, we show that one of the Phytophthora RXLR effector, Avrblb2, interacts with calmodulin at the plasma membrane of the plant cells. Using deletion and single amino acid mutagenesis, we found that calmodulin binds to the effector domain of Avrblb2. In addition, we show that most known homologs of Avrblb2 in three different Phytophthora species interact with different isoforms of calmodulin. Type of amino acids at position 69 in Avrblb2, which determines Rbi-blb2 resistance protein-mediated defense responses, is not involved in the Avrblb2-calmodulin interaction. Using in planta functional analyses, we show that calmodulin binding to Avrblb2 is required for its recognition by Rpi-blb2 to incite hypersensitive response. These findings suggest that Avrblb2 by interacting with calmodulin interfere with plant defense associated Ca2+ signaling in plants.
DOI: 10.3389/fpls.2019.00374
PubMed: 30984224
PubMed Central: PMC6447682
Affiliations:
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Afzal Naveed</name><affiliation wicri:level="2"><nlm:affiliation>Mid-Florida Research and Education Center, Department of Plant Pathology, University of Florida, Apopka, FL, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mid-Florida Research and Education Center, Department of Plant Pathology, University of Florida, Apopka, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Bibi, Shaheen" sort="Bibi, Shaheen" uniqKey="Bibi S" first="Shaheen" last="Bibi">Shaheen Bibi</name><affiliation wicri:level="2"><nlm:affiliation>Mid-Florida Research and Education Center, Department of Plant Pathology, University of Florida, Apopka, FL, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mid-Florida Research and Education Center, Department of Plant Pathology, University of Florida, Apopka, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Ali, Gul Shad" sort="Ali, Gul Shad" uniqKey="Ali G" first="Gul Shad" last="Ali">Gul Shad Ali</name><affiliation wicri:level="2"><nlm:affiliation>Mid-Florida Research and Education Center, Department of Plant Pathology, University of Florida, Apopka, FL, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mid-Florida Research and Education Center, Department of Plant Pathology, University of Florida, Apopka, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><series><title level="j">Frontiers in plant science</title><idno type="ISSN">1664-462X</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In plants, subcellular fluctuations in Ca<sup>2+</sup> ion concentration are among the earliest responses to biotic and abiotic stresses. Calmodulin, which is a ubiquitous Ca<sup>2+</sup> ion sensor in eukaryotes, plays a major role in translating these Ca<sup>2+</sup> signatures to cellular responses by interacting with numerous proteins located in plasma membranes, cytoplasm, organelles and nuclei. In this report, we show that one of the <i>Phytophthora</i> RXLR effector, Avrblb2, interacts with calmodulin at the plasma membrane of the plant cells. Using deletion and single amino acid mutagenesis, we found that calmodulin binds to the effector domain of Avrblb2. In addition, we show that most known homologs of Avrblb2 in three different <i>Phytophthora</i> species interact with different isoforms of calmodulin. Type of amino acids at position 69 in Avrblb2, which determines Rbi-blb2 resistance protein-mediated defense responses, is not involved in the Avrblb2-calmodulin interaction. Using <i>in planta</i> functional analyses, we show that calmodulin binding to Avrblb2 is required for its recognition by Rpi-blb2 to incite hypersensitive response. These findings suggest that Avrblb2 by interacting with calmodulin interfere with plant defense associated Ca<sup>2+</sup> signaling in plants.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">30984224</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>29</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1664-462X</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><PubDate><Year>2019</Year></PubDate></JournalIssue><Title>Frontiers in plant science</Title><ISOAbbreviation>Front Plant Sci</ISOAbbreviation></Journal><ArticleTitle>The <i>Phytophthora</i> RXLR Effector Avrblb2 Modulates Plant Immunity by Interfering With Ca<sup>2+</sup> Signaling Pathway.</ArticleTitle><Pagination><MedlinePgn>374</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fpls.2019.00374</ELocationID><Abstract><AbstractText>In plants, subcellular fluctuations in Ca<sup>2+</sup> ion concentration are among the earliest responses to biotic and abiotic stresses. Calmodulin, which is a ubiquitous Ca<sup>2+</sup> ion sensor in eukaryotes, plays a major role in translating these Ca<sup>2+</sup> signatures to cellular responses by interacting with numerous proteins located in plasma membranes, cytoplasm, organelles and nuclei. In this report, we show that one of the <i>Phytophthora</i> RXLR effector, Avrblb2, interacts with calmodulin at the plasma membrane of the plant cells. Using deletion and single amino acid mutagenesis, we found that calmodulin binds to the effector domain of Avrblb2. In addition, we show that most known homologs of Avrblb2 in three different <i>Phytophthora</i> species interact with different isoforms of calmodulin. Type of amino acids at position 69 in Avrblb2, which determines Rbi-blb2 resistance protein-mediated defense responses, is not involved in the Avrblb2-calmodulin interaction. Using <i>in planta</i> functional analyses, we show that calmodulin binding to Avrblb2 is required for its recognition by Rpi-blb2 to incite hypersensitive response. These findings suggest that Avrblb2 by interacting with calmodulin interfere with plant defense associated Ca<sup>2+</sup> signaling in plants.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Naveed</LastName><ForeName>Zunaira Afzal</ForeName><Initials>ZA</Initials><AffiliationInfo><Affiliation>Mid-Florida Research and Education Center, Department of Plant Pathology, University of Florida, Apopka, FL, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bibi</LastName><ForeName>Shaheen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Mid-Florida Research and Education Center, Department of Plant Pathology, University of Florida, Apopka, FL, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ali</LastName><ForeName>Gul Shad</ForeName><Initials>GS</Initials><AffiliationInfo><Affiliation>Mid-Florida Research and Education Center, Department of Plant Pathology, University of Florida, Apopka, FL, United States.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>03</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Plant Sci</MedlineTA><NlmUniqueID>101568200</NlmUniqueID><ISSNLinking>1664-462X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AVRblb2 effector</Keyword><Keyword MajorTopicYN="N">RXLR effector</Keyword><Keyword MajorTopicYN="N">Rpi-blb2</Keyword><Keyword MajorTopicYN="N">calcium signaling</Keyword><Keyword MajorTopicYN="N">calmodulin (CAM)</Keyword><Keyword MajorTopicYN="N">plant-Phytophthora interactions</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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